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EMBL scientists co-initiated the reconstruction of the most diverse set of reference human genomes ever assembled. In , the International Human Genome Sequencing Consortium announced the first draft of the human genome reference sequence. The Human Genome Project had taken more than 11 years of work and involved more than 1, scientists from 40 countries. The reference sequence, however, does not represent a single individual but instead is a composite of genomes from several individuals that cannot accurately capture the complexity of human genetic variation. Building on this, scientists have carried out many sequencing projects over the past 20 years to identify and catalogue genetic differences between individual genomes and the reference genome. These differences usually focused on small changes of a single letter of the DNA code and missed larger genetic alterations.

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Binding of transcription factors measured on individual DNA molecules in living cells. An important question in the field of gene regulation is how a limited set of transcription factors interpret the same genome in different ways to create over cell types found in our bodies, all of which are defined by the expression of a unique set of genes. To achieve this, transcription factors have evolved cooperative mechanisms to enable precise control of gene expression. In a new study, members of the Krebs group in the Genome Biology Unit at EMBL Heidelberg have developed a method to directly visualise how transcription factors co-occupy DNA in living cells, and have used it to better understand their cooperativity mechanisms. Transcription factors are proteins that bind to specific regulatory DNA sequences to control which genes are turned on or off. For transcription factors to activate regulatory regions of the DNA, histones typically need to be removed so the transcription factors can access their recognition sites. Transcription factors often work collectively to achieve this task — scientists speak of cooperativity.

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A young gay man with cerebral palsy branches out from his insular existence in hopes of finally going after the life he wants. In the wake of being hit by a car, Ryan begins a coveted internship and finds an opportunity to redefine himself based on his recent run-in. Karen reluctantly agrees to help Ryan find an apartment while Kim eagerly volunteers to help him check another big milestone off his list.
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