What is the stain? Diffuse heterogenous lymphocyte infiltrate with occasional plasma cells and prominent giant cells. Through multiple choice questions and histologic unknowns, this video will help medical students learn how to histologically date a myocardial infarct. Myocardial Infarction - HistopathologyCoagulative necrosis- Pyknosis, Karyorrhexis, Karyolysis- acute inflammation, chronic inflammation, granulation tissue
Myocardial Infarction (Heart Attack) — STEMI vs. NSTEMI
Myocardial infarction - Wikipedia
A diagnosis of myocardial infarction is created by integrating the history of the presenting illness and physical examination with electrocardiogram findings and cardiac markers blood tests for heart muscle cell damage. At autopsy , a pathologist can diagnose a myocardial infarction based on anatomopathological findings. A chest radiograph and routine blood tests may indicate complications or precipitating causes and are often performed upon arrival to an emergency department. New regional wall motion abnormalities on an echocardiogram are also suggestive of a myocardial infarction. Echo may be performed in equivocal cases by the on-call cardiologist.
Final Diagnosis -- Acute Myocardial Infarction
Background: Three types of necrosis characterize MI: coagulation necrosis, typically due to a coronarogenic mechanism, coagulative myocytolysis with formation of contract bands as an effect of sympathetic nervous system and adrenergic stimulation, and colliquative myocytolysis, characterized by myocardial fiber lysis, which is a close result of hydrolytic enzyme activity deriving from the material reaching the infarct area. Methods: Although a multifactorial etiology may be identified, nevertheless coronary alterations, which are a consequence of atherosclerotic plaque formation and complications with a reduced blood flow supply to the myocardium, are the benchmark of MI. Results: Evidence indicates a close relationship between the MI and some coronary risk factors, associated with this pathologic pattern with a different, but high rate.
Heart is a complex assembly of many cell types constituting myocardium, endocardium and epicardium that intensively communicate to each other in order to maintain the proper cardiac function. There are many types of intercellular intracardiac signals, with a prominent role of extracellular vesicles EVs , such as exosomes and microvesicles, for long-distant delivering of complex messages. Cardiomyocytes release EVs, whose content could significantly vary depending on the stimulus.