Metrics details. One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that recently-evolved genomic regions in humans are involved in the genetic risk for schizophrenia. Using summary statistics from genome-wide association studies GWAS of schizophrenia and 11 other phenotypes, we tested for enrichment of association with GWAS traits in regions that have undergone methylation changes in the human lineage compared to Neanderthals and Denisovans, i. We used analytical tools that evaluate polygenic enrichment of a subset of genomic variants against all variants.
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Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max. Manual assertion based on experiment in i. Manual assertion according to rules i. Manual assertion inferred from combination of experimental and computational evidence i.
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Searching for archaic contribution in Africa. Annals of Human Biology IF 1. However, once humans dispersed beyond Africa, the history of those who stayed remains vastly under-studied, lacking the proper attention the birthplace of both modern and archaic humans deserves.
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